Phylonix - Zebrafish Assays for Drug Screening
   
   
   
   
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Publications and Abstracts
       
   

Manuscripts

  1. McGrath, P. and C. Q. Li (2008). "Zebrafish: a predictive model for assessing drug-induced toxicity." Drug Discov. Today 13(9-10): 394-401.
  2. Beuerle, F., P. Witte, et al. (2007). "Cytoprotective activities of water-soluble fullerenes in zebrafish models." J Exp Nanosci 2(3): 147-70.
  3. Parng, C., Roy, N.M., Ton, C., Lin, Y. and McGrath, P. Neurotoxicity assessment using zebrafish. J Pharmacol Toxicol Methods 2007; 55(1):103-112.
  4. Haldi, M., Ton, C., Seng, W.L. and McGrath, P. Human melanoma cells transplanted into zebrafish proliferate, migrate, produce melanin, form masses and stimulate angiogenesis in zebrafish.  Angiogenesis 2006; 9:139-151.
  5. Ton, C., Lin, Y. and Willett, C. Zebrafish as a model for developmental neurotoxicity testing.  Birth Defects Research Part A: Clinical and Molecular Teratology 2006; 76(7):553-67.
  6. Parng, C., Ton, C., Lin, Y., Roy, N.M. and McGrath, P. A zebrafish assay for identifying neuroprotectants in vivo. Neurotoxicology and Teratology 2006; 28(4):509-16.
  7. Ton C., Parng C. The use of zebrafish for assessing ototoxic and otoprotective agents.  Hearing Research. 2005 Oct; 208(1-2): 79-88.
  8. Parng, C. In vivo zebrafish assays for toxicity testing.  Current Opinion in Drug Discovery & Development. 2005; 8(1):100-106.
  9. Seng, W.L., En, K., Lee, J. and McGrath, P. Use of a monoclonal antibody specific for activated endothelial cells to quantitate angiogenesis in vivo in zebrafish after drug treatment. Angiogenesis. 2004;7(3):243-53.
  10. Ma, C. Animal models of disease. Modern Drug Discovery. June 2004. 30-36.
  11. Parng, C., Anderson, N., Ton, C., and McGrath, P. 2004. Zebrafish apoptosis assay for drug discovery. Methods in Cell Biology 2004;76:75-85.
  12. Ma, C, Parng, C.L., Seng, W.L., Zhang, C., Willett, C., and McGrath, P. Zebrafish: An in vivo model for drug screening. Innovations in Pharmaceutical Technologies. Nov. 2003. 38-45.
  13. Zhang, C., Willett, C., Fremgen, T. 2003. Zebrafish: An animal model for toxicological studies. Current Protocols in Toxicology, John W Wiley & Sons, Inc., NY., Unit 1.7, Supplement 17, August, 1.7.1-1.7.18.
  14. Seng, W.L. and McGrath, P. 2002. A high throughput in vivo zebrafish angiogenesis assay. Drug Plus International 1(2): 22-24.
  15. Parng, C., Seng W.L. and McGrath P. 2002. Zebrafish: A preclinical model for drug screening. Assay and Drug Development Technologies 1(1): 41-48.
  16. Serbedzija, G.N., Flynn, E. and Willett, C.E. 2000. Zebrafish angiogenesis: A new model for drug screening. Angiogenesis 3(4):353-359.

Abstracts

  1. Chemicals induce developmental neurotoxicity in zebrafish C. Q. Li, L. J. D’Amico, W. L. Seng, P. McGrath. American College of Toxicology 2007
  2. In vivo assessment of drug effects on zebrafish liver and kidney C. Q. Li, L.J. D’Amico, W. L. Seng, P. McGrath. American College of Toxicology 2007
  3. Determination of Lc50 and visual assessment of compound induced developmental toxicity on zebrafish body, liver, intestine and heart W. L. Seng 1, C. Parng,1 K.A. Augustine 2, P. McGrath 1, PHYLONIX, Cambridge, MA 1 BRISTOL-MYERS SQUIBB 2 Pharmaceutical Research Institute, Department of Reproductive Toxicology, Hopewell, New Jersey.Society of Toxicology 2007
  4. Assessment of compound induced heart, gastrointestinal tract, liver, and kidney toxicity in zebrafish P. McGrath.1, C.Parng 1, K.A. Augustine 2, W. L. Seng 1, PHYLONIX, Cambridge, MA 1 BRISTOL-MYERS SQUIBB 2 Pharmaceutical Research Institute, Department of Reproductive Toxicology, Hopewell, New Jersey. Society of Toxicology 2007
  5. Assessment of drug effects on cardiac repolarization in adult zebrafish by ECG W. L. Seng, C. Parng, P. McGrath. Society of Toxicology 2007
  6. Zebrafish: a new animal model for identifying drugs that inhibit choroidal neovascularization L. Zhong, P. McGrath, W.L. Seng. Association of Research in Vision and Ophthalmology 2007
  7. Assessment of drug effects on cardiac functions, including qt prolongation using zebrafish D. Park, W. L. Seng, C. Q. Li, P. McGrath, X. Tang. International Congress of Toxicology 2007
  8. Chemical exposure induces developmental neurotoxicity in zebrafish C. Q. Li, L. J. D’Amico, W. L. Seng, P. McGrath. International Congress of Toxicology 2007
  9. Zebrafish: a good model for assessing drug effects on the gastrointestinal system and kidney W. L. Seng , C. Q. Li, D. Park, P. McGrath. International Congress of Toxicology 2007
  10. Whole zebrafish cytochrome p450 microplate assays for assessing drug metabolism and drug safety C. Q. Li, W. L. Seng, P. McGrath. Society of Toxicology 2008
  11. ECG assessment of drug-induced proarrhythmia in adult zebrafish D. Park, W. L. Seng, C. Q. Li, X. Tang, L. J. D’Amico, P. McGrath. Society of Toxicology 2008
  12. Developmental neurotoxicity assessment in zebrafish: a survey of 200 environmental toxicants L. J. D’Amico, C.Q Li, W. L. Seng, P. McGrath. Society of Toxicology 2008